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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
37.27
Human Site:
T382
Identified Species:
58.57
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
T382
K
R
M
T
R
F
F
T
K
L
D
A
D
K
S
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
T382
K
R
M
T
R
F
F
T
K
L
D
A
D
K
S
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
T382
K
R
M
T
R
F
F
T
K
L
D
A
D
K
S
Dog
Lupus familis
XP_852191
460
52810
T366
K
R
M
T
R
F
F
T
K
L
D
A
D
K
S
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
T382
K
R
M
T
R
F
F
T
K
L
D
A
D
K
S
Rat
Rattus norvegicus
Q91ZN7
476
54410
T382
K
R
M
T
R
F
F
T
K
L
D
A
D
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
T382
K
R
M
T
R
F
F
T
K
L
D
A
D
R
S
Chicken
Gallus gallus
Q8AYC9
476
53830
T382
R
R
M
T
R
F
F
T
K
L
D
A
D
G
S
Frog
Xenopus laevis
Q6DE87
474
53957
T381
K
R
M
T
R
F
F
T
K
V
N
A
E
S
S
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
I333
I
A
L
R
D
S
C
I
A
L
G
H
T
W
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
S394
M
N
Q
T
Q
N
A
S
Q
N
Y
F
Q
R
L
Honey Bee
Apis mellifera
XP_623436
467
53927
C380
T
V
K
R
L
I
N
C
L
K
D
E
N
Y
T
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
V402
S
E
H
A
G
F
G
V
R
E
T
D
D
Y
R
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
L382
S
C
G
C
E
K
T
L
K
V
L
T
T
T
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
A343
K
R
E
T
R
F
A
A
K
G
A
A
N
D
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
86.6
73.3
6.6
N.A.
6.6
6.6
13.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
93.3
13.3
N.A.
33.3
20
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
14
7
7
0
7
67
0
0
0
% A
% Cys:
0
7
0
7
0
0
7
7
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
60
7
60
7
0
% D
% Glu:
0
7
7
0
7
0
0
0
0
7
0
7
7
0
0
% E
% Phe:
0
0
0
0
0
74
60
0
0
0
0
7
0
0
0
% F
% Gly:
0
0
7
0
7
0
7
0
0
7
7
0
0
7
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
7
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% I
% Lys:
60
0
7
0
0
7
0
0
74
7
0
0
0
40
7
% K
% Leu:
0
0
7
0
7
0
0
7
7
60
7
0
0
0
20
% L
% Met:
7
0
60
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
7
7
0
0
7
7
0
14
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
7
0
7
0
0
0
7
0
0
0
7
0
0
% Q
% Arg:
7
67
0
14
67
0
0
0
7
0
0
0
0
14
7
% R
% Ser:
14
0
0
0
0
7
0
7
0
0
0
0
0
7
60
% S
% Thr:
7
0
0
74
0
0
7
60
0
0
7
7
14
7
7
% T
% Val:
0
7
0
0
0
0
0
7
0
14
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
0
14
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _